Respiratory clinical trials

Diamond

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination with the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications

This study is currently recruiting participants (flu season).

Primary Objective: This double-blind (neither researchers nor participants know what treatment participant is receiving) study will evaluate efficacy/safety of pimodivir in combination with SOC treatment versus placebo in combination with SOC treatment in adolescent (13 to 17 years), adult (18 to 65 years), and elderly (greater than [>] 65 but less than or equal to [<=] 85 years) non-hospitalized participants with influenza A infection who are at risk of developing complications.

Principal Investigator: James Taylor

Study Coordinator: Marina Dzhelali

Trial Website: https://clinicaltrials.gov/ct2/show/NCT03381196

Flagstone

Study to Assess Efficacy and Safety of Baloxavir Marboxil in Combination with Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza

This study is currently recruiting participants (flu season).

Primary Objective: This study will evaluate the efficacy, safety, and pharmacokinetics of baloxavir marboxil in combination with a standard-of-care (SOC) neuraminidase inhibitor (NAI) (i.e., oseltamivir, zanamivir, or peramivir) compared with a matching placebo in combination with a SOC NAI in hospitalized patients with influenza.

Principal Investigator: James Taylor

Study Coordinator: Michelle Hennessy

Trial Website: https://clinicaltrials.gov/ct2/show/NCT03684044

Sapphire

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination with the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

This study is currently recruiting participants (flu season).

Primary Objective: This double-blind (neither researchers nor participants know what treatment participant is receiving) study will evaluate efficacy/safety of pimodivir in combination with SOC treatment versus placebo in combination with SOC treatment in adolescent, adult, and elderly hospitalized participants with influenza A infection.

Principal Investigator: James Taylor

Study Coordinator: Marina Dzhelali

Trial Website: https://clinicaltrials.gov/ct2/show/NCT03376321